This talk explores the question of resistance through the lens of a phenomenology of fatigue. It argues that the term “fatigue” covers a plurality of distinct experiential structures unfolding on different levels: individual, relational, and social-political. Each form of fatigue transforms our presence to ourselves, our capacity to act, our relation to others, and our way of inhabiting the world. Accordingly, different fatigues call for different forms of resistance. Yet, the notion of resistance itself proves to be fundamentally ambivalent, since it designates both the resistance encountered in the world, from which fatigue arises, and the the resistance by which the subject responds to fatigue. The talk argues that these two senses are intrinsically connected and illuminate one another, thereby disclosing the phenomenological structure of both fatigue and resistance.