In what follows, I offer a general methodology for the analysis of the roles that technologically produced images play in scientific debate. This requires a review of insights into the philosophy of technology emerging from a budding perspective called "postphenomenology'. This perspective, which amalgamates central aspects of the phenomenological and pragmatic traditions of philosophy and applies them to issues of technology, offers a rich collection of concepts for the project of articulating the ways that technologies mediate people's experience of the world. The methodology I provide below applies postphenomenological insights for both the purposes of understanding practices of image interpretation in science, and potentially offering novel research directions for contemporary scientific work.