This chapter undertakes an investigation of the productive possibilities engendered by nihilism for the experimental project of "trans-human" philosophy. While viewed by some critics as an event of strictly negative and stultifying consequence, the advent of European nihilism may actually furnish an interpretive context within which philosophers might finally "let drop" their nagging anthropocentric prejudices. Against the blighted backdrop of European nihilism, that is, philosophers might progress significantly toward (and eventually complete?) the untimely agenda set for them by Friedrich Nietzsche: "to translate man back into Nature" (Nietzsche 1989, 230), and thus behold the world in its sheer, amoral immanence.