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I wish to discuss some rather incomplete ideas concerning difficulties that arise in some parts of quantum mechanics. In general there have been no serious difficulties when we are dealing with a finite number of particles, but very essential difficulties arise as soon as we treat a system having an infinite number of degrees of freedom; for example, the theory of holes, which, because of the pair generation, requires an indefinite number of particles; also the Dirac non-relativistic theory of light and the Pauli-Heisenberg relativistic quantum electro-dynamics, these being equivalent to systems consisting of an infinite number of particles.