The first part of this chapter introduces the problem of medically unexplained symptoms (MUS) and explains why we need an alternative theoretical understanding of psychosomatics in order to grasp the idea of a "speaking body." The theoretical and clinical problems connecting to psychosomatic pathology are presented. The failure of traditional psychosomatic theories (psychodynamic, psychosomatic medicine and stress theory) to make psychosomatics comprehensible is demonstrated through text analyses, philosophical argumentation and exemplification from the literature. The final part of this chapter presents empirical evidence that psychosomatic symptoms in adults and children/young adults are common causes for seeking health care today. Four clinical challenges connected to the treatment of these patients is presented and discussed at the end of this first introductory chapter.